CD59

CD59
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CDQ、1CDR、1CDS、1ERG、1ERH、2J8B、2OFS、2UWR、2UX2、4BIK
識別號
别名	CD59；, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule, CD59 molecule (CD59 blood group)
外部ID	OMIM：107271 MGI：1888996 HomoloGene：56386 GeneCards：CD59
基因位置（人类）
染色体	染色体11（人类）[1]
终止	33,736,491 bp[1]
基因位置（小鼠）
染色体	染色体2（小鼠）[2]
终止	104,091,187 bp[2]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • complement binding;
細胞組分	• 囊泡; • endoplasmic reticulum membrane; • 膜; • 粘着斑; • Golgi membrane; • 细胞膜; • 細胞外區域; • cell surface; • compact myelin; • anchored component of external side of plasma membrane; • ER to Golgi transport vesicle membrane; • anchored component of membrane; • 肌膜; • 外排體; • endoplasmic reticulum-Golgi intermediate compartment membrane; • 細胞外空間; • specific granule membrane; • tertiary granule membrane; • transport vesicle;
生物學過程	• 凝血; • negative regulation of apoptotic process; • negative regulation of activation of membrane attack complex; • ER to Golgi vesicle-mediated transport; • cell surface receptor signaling pathway; • COPII vesicle coating; • positive regulation of T cell proliferation; • regulation of complement activation; • cell activation; • neutrophil degranulation; • regulation of complement-dependent cytotoxicity;
	Sources:Amigo / QuickGO
直系同源
	966
	333883
	ENSG00000085063
	ENSMUSG00000068686
	P13987; Q6FHM9
	P58019
	NM_203331、NM_000611、NM_001127223、NM_001127225、NM_001127226、NM_001127227、NM_203329、NM_203330
	NM_181858、XM_006499801、XM_006499802、XM_006499803、XM_006499805、XM_017319062、NM_001368215
	NP_000602、NP_001120695、NP_001120697、NP_001120698、NP_001120699、NP_976074、NP_976075、NP_976076; NP_000602.1、NP_001120695.1、NP_001120697.1、NP_001120698.1、NP_001120699.1、NP_976074.1、NP_976075.1、NP_976076.1
	NP_862906、XP_006499864、XP_006499865、XP_006499866、XP_006499868、XP_017174551、NP_001355144
	維基數據

CD59，亦稱為「膜攻擊複合物（MAC）抑制蛋白」（MAC-inhibitory protein, MAC-IP）、「膜反应性溶血抑制物」（membrane inhibitor of reactive lysis, MIRL）、「膜攻擊複合物抑制因子」（membrane attack complex inhibitory factor, MACIF）或保護素（protectin）[5]，在人體內是一種由CD59基因編碼的糖蛋白，屬於分化簇（Cluster of Differntiation, CD）的一種[6]。CD59屬於LY6/uPAR/α-神經毒素蛋白家族[7]。 CD59通過糖化肌醇磷脂（GPI）基團錨定在細胞膜上。當補體系統激活並已產生C5b6 7 8複合物時，CD59會阻止補體成分C9聚集到上述複合體上，從而阻止膜攻擊複合物（MAC）的形成[8]。同時，細胞也會收到信號，通過胞吞作用攝入CD59-CD9複合物[7]。

能影響GPI基團的突變會引起紅細胞膜上的CD59分子和衰變加速因子（CD55）數量減少，可引發陣發性夜間血紅素尿症[9]。

部分病毒，例如HIV、巨細胞病毒、牛痘病毒能夠通過將宿主細胞的CD59整合到自己的包膜上來逃避補體系統的攻擊[10]。

參見

參考

GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000068686 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. [2018-05-19]. （原始内容存档于2019-02-15）.
.
Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E. . international journal of oncology. Aug 1998, 13 (2): 305–18. PMID 9664126. doi:10.3892/ijo.13.2.305.
Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S. . J. Biol. Chem. September 2006, 281 (37): 27398–27404. PMID 16844690. doi:10.1074/jbc.M603690200.
Parker C, Omine M, Richards S, 等. . Blood. 2005, 106 (12): 3699–709 [2018-04-27]. PMC 1895106. PMID 16051736. doi:10.1182/blood-2005-04-1717. （原始内容存档于2009-09-18）.
Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. . Mol. Immunol. July 2004, 41 (6–7): 583–597. PMID 15219997. doi:10.1016/j.molimm.2004.04.007.

拓展閱讀

Tandon N, Morgan BP, Weetman AP. . Immunology. 1992, 75 (2): 372–7. PMC 1384722. PMID 1372592.
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Hahn WC, Menu E, Bothwell AL, 等. . Science. 1992, 256 (5065): 1805–1807. PMID 1377404. doi:10.1126/science.1377404.
Ninomiya H, Sims PJ. . J. Biol. Chem. 1992, 267 (19): 13675–80. PMID 1377690.
Petranka JG, Fleenor DE, Sykes K, 等. . Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (17): 7876–7879. PMC 49817. PMID 1381503. doi:10.1073/pnas.89.17.7876.
Motoyama N, Okada N, Yamashina M, Okada H. . Eur. J. Immunol. 1992, 22 (10): 2669–2673. PMID 1382994. doi:10.1002/eji.1830221029.
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Philbrick WM, Palfree RG, Maher SE, 等. . Eur. J. Immunol. 1990, 20 (1): 87–92. PMID 1689664. doi:10.1002/eji.1830200113.
Sawada R, Ohashi K, Anaguchi H, 等. . DNA Cell Biol. 1990, 9 (3): 213–220. PMID 1692709. doi:10.1089/dna.1990.9.213.
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Rooney IA, Morgan BP. . Immunology. 1991, 71 (3): 308–11. PMC 1384423. PMID 1702747.
Watts MJ, Dankert JR, Morgan EP. . Biochem. J. 1990, 265 (2): 471–7. PMC 1136908. PMID 2302178.
Okada H, Nagami Y, Takahashi K, 等. . Biochem. Biophys. Res. Commun. 1989, 162 (3): 1553–1559. PMID 2475111. doi:10.1016/0006-291X(89)90852-8.
Davies A, Simmons DL, Hale G, 等. . J. Exp. Med. 1989, 170 (3): 637–654. PMC 2189447. PMID 2475570. doi:10.1084/jem.170.3.637.
Sawada R, Ohashi K, Okano K, 等. . Nucleic Acids Res. 1989, 17 (16): 6728–6728. PMC 318369. PMID 2476718. doi:10.1093/nar/17.16.6728.
Sugita Y, Tobe T, Oda E, 等. . J. Biochem. 1990, 106 (4): 555–7. PMID 2606909.
Bora NS, Gobleman CL, Atkinson JP, 等. . Invest. Ophthalmol. Vis. Sci. 1994, 34 (13): 3579–84. PMID 7505007.
Kieffer B, Driscoll PC, Campbell ID, 等. . Biochemistry. 1994, 33 (15): 4471–4482. PMID 7512825. doi:10.1021/bi00181a006.
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外部連結

MeSH（醫學主題詞）上面的CD59+Antigen（美式英语）
Human CD59 genome location and CD59 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068686 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . [2018-05-19]. （原始内容存档于2019-02-15）.

[6] .

[pmid9664126-7] Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E. . international journal of oncology. Aug 1998, 13 (2): 305–18. PMID 9664126. doi:10.3892/ijo.13.2.305.

[pmid16844690-8] Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S. . J. Biol. Chem. September 2006, 281 (37): 27398–27404. PMID 16844690. doi:10.1074/jbc.M603690200.

[parker2005-9] Parker C, Omine M, Richards S, 等. . Blood. 2005, 106 (12): 3699–709 [2018-04-27]. PMC 1895106. PMID 16051736. doi:10.1182/blood-2005-04-1717. （原始内容存档于2009-09-18）.

[pmid15219997-10] Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. . Mol. Immunol. July 2004, 41 (6–7): 583–597. PMID 15219997. doi:10.1016/j.molimm.2004.04.007.