KIRREL
KIRREL(、類IRRE蛋白1系屬、亦被稱為NEPH1)是一種由KIRREL基因所編碼的人類蛋白質。[1][2]
類IRRE系屬(果蠅) () | |||
---|---|---|---|
标识 | |||
代号 | KIRREL; NEPH1 | ||
扩展标识 | 遗传学:607428 同源基因:10089 GeneCards: KIRREL Gene | ||
RNA表达模式 | |||
更多表达数据 | |||
直系同源体 | |||
物种 | 人类 | 小鼠 | |
Entrez | 55243 | 170643 | |
Ensembl | ENSG00000183853 | ENSMUSG00000041734 | |
UniProt | Q96J84 | Q80W68 | |
mRNA序列 | NM_018240 | NM_001170985 | |
蛋白序列 | NP_060710 | NP_001164456 | |
基因位置 |
Chr 1: 157.96 – 158.07 Mb |
Chr 3: 87.08 – 87.17 Mb | |
PubMed查询 | |||
NEPH1是屬於「類腎病蛋白樣蛋白質家族」的成員,其包括NEPH2(MIM607761)及NEPH3(KIRREL2、MIM607762)。這些蛋白的「胞質結構域」(cytoplasmic domain)與足蛋白(NPHS2;MIM 604766)的C末端交互作用。NEPH1用表達腎臟足細胞濾過裂隙,細胞涉及確保血液的大小及電荷選擇性的超濾作用(Sellin et al., 2003)。[由OMIM供給][2]
註釋
- Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G. . FASEB J. Jan 2003, 17 (1): 115–7. PMID 12424224. doi:10.1096/fj.02-0242fje.
- . (原始内容存档于2019-10-17).
- Liu, Gang; Kaw Beenu; Kurfis Jayson; Rahmanuddin Syed; Kanwar Yashpal S; Chugh Sumant S. . J. Clin. Invest. (United States). Jul 2003, 112 (2): 209–21. ISSN 0021-9738. PMC 164293. PMID 12865409. doi:10.1172/JCI18242.
- Gerke, Peter; Huber Tobias B; Sellin Lorenz; Benzing Thomas; Walz Gerd. . J. Am. Soc. Nephrol. (United States). Apr 2003, 14 (4): 918–26. ISSN 1046-6673. PMID 12660326. doi:10.1097/01.ASN.0000057853.05686.89.
- Huber, Tobias B; Schmidts Miriam; Gerke Peter; Schermer Bernhard; Zahn Anne; Hartleben Björn; Sellin Lorenz; Walz Gerd; Benzing Thomas. . J. Biol. Chem. (United States). Apr 2003, 278 (15): 13417–21. ISSN 0021-9258. PMID 12578837. doi:10.1074/jbc.C200678200.
延伸閱讀
- Donoviel DB, Freed DD, Vogel H; 等. . Mol. Cell. Biol. 2001, 21 (14): 4829–36. PMC 87176. PMID 11416156. doi:10.1128/MCB.21.14.4829-4836.2001.
- Strausberg RL, Feingold EA, Grouse LH; 等. . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Huber TB, Schmidts M, Gerke P; 等. . J. Biol. Chem. 2003, 278 (15): 13417–21. PMID 12578837. doi:10.1074/jbc.C200678200.
- Barletta GM, Kovari IA, Verma RK; 等. . J. Biol. Chem. 2003, 278 (21): 19266–71. PMID 12646566. doi:10.1074/jbc.M301279200.
- Gerke P, Huber TB, Sellin L; 等. . J. Am. Soc. Nephrol. 2003, 14 (4): 918–26. PMID 12660326. doi:10.1097/01.ASN.0000057853.05686.89.
- Liu G, Kaw B, Kurfis J; 等. . J. Clin. Invest. 2003, 112 (2): 209–21. PMC 164293. PMID 12865409. doi:10.1172/JCI18242.
- Ota T, Suzuki Y, Nishikawa T; 等. . Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Brill LM, Salomon AR, Ficarro SB; 等. . Anal. Chem. 2004, 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d.
- Gerhard DS, Wagner L, Feingold EA; 等. . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Kitamura A, Tsukaguchi H, Iijima K; 等. . Nephrol. Dial. Transplant. 2007, 21 (11): 3133–8. PMID 16968734. doi:10.1093/ndt/gfl347.
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