RAD51
Rad51是真核生物體內的一種蛋白質,与原核生物的RecA同源,是一种高度保守的蛋白,從酵母菌到人類之間的變異不大。人類的Rad51含有339個氨基酸,於同源重組中扮演主要角色,參與搜尋同源部位與DNA的配對過程。
RAD51 | |
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Rad51結構圖。來源:PDB 1SZP[6] | |
識別 | |
符號 | RAD51 |
替換符號 | RAD51A, RECA |
Entrez | 5888 |
HUGO | 9817 |
OMIM | 179617 |
PDB | 1SZP |
RefSeq | NM_002875 |
UniProt | Q06609 |
其他資料 | |
基因座 | 15號 q15.1 |
人類的Rad51的基因位於第15號染色體。包括此基因在內,哺乳類共有七種類似recA的基因,包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1[7]。
參考文獻
- .
- GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000027323 - Ensembl, May 2017
- . National Center for Biotechnology Information, U.S. National Library of Medicine.
- . National Center for Biotechnology Information, U.S. National Library of Medicine.
- 页面存档备份,存于 Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004
- Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)
- Galkin,V .E. et al. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)
- Pellegrini, L. et al. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)
外部連結
- MeSH(醫學主題詞)上面的RAD51+Protein(美式英语)
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