RAD51

RAD51
	Rad51結構圖。來源：PDB 1SZP[6]
識別
符號	RAD51
替換符號	RAD51A, RECA
Entrez	5888
HUGO	9817
OMIM	179617
PDB	1SZP
RefSeq	NM_002875
UniProt	Q06609
其他資料
基因座	15號 q15.1

RAD51
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1N0W、1B22
識別號
别名	RAD51；, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
外部ID	OMIM：179617 MGI：97890 HomoloGene：2155 GeneCards：RAD51
相關疾病
	Fanconi anemia complementation group R[1]
基因位置（人类）
染色体	染色体15（人类）[2]
终止	40,732,340 bp[2]
基因位置（小鼠）
染色体	染色体2（小鼠）[3]
终止	119,147,445 bp[3]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• 核苷酸結合; • DNA结合; • DNA-dependent ATPase activity; • recombinase activity; • DNA polymerase binding; • protein C-terminus binding; • 血浆蛋白结合; • four-way junction DNA binding; • 相同蛋白质结合; • endodeoxyribonuclease activity; • ATP結合; • single-stranded DNA binding; • double-stranded DNA binding; • single-stranded DNA helicase activity; • chromatin binding; • 酶结合;
細胞組分	• 細胞質; • site of double-strand break; • PML body; • 细胞骨架; • 核质; • 微管组织中心; • nuclear chromosome; • 线粒体基质; • 核仁; • 線粒體; • 细胞质的核周区域; • 染色质; • 细胞核; • nuclear chromatin; • 细胞质基质; • 大分子复合体; • nuclear chromosome, telomeric region; • condensed chromosome; • condensed nuclear chromosome; • lateral element; • 染色体;
生物學過程	• strand invasion; • mitotic recombination-dependent replication fork processing; • reciprocal meiotic recombination; • DNA重组; • regulation of double-strand break repair via homologous recombination; • DNA代谢过程; • positive regulation of DNA ligation; • cellular response to camptothecin; • double-strand break repair via homologous recombination; • cellular response to ionizing radiation; • mitotic recombination; • protein homooligomerization; • DNA修復; • DNA unwinding involved in DNA replication; • cellular response to DNA damage stimulus; • interstrand cross-link repair; • DNA recombinase assembly; • negative regulation of G0 to G1 transition; • telomere maintenance via recombination; • telomere maintenance via telomere lengthening; • replication fork processing; • 减数分裂; • chromosome organization involved in meiotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	5888
	19361
	ENSG00000051180
	ENSMUSG00000027323
	Q06609
	Q08297
	XM_011521862、NM_001164269、NM_001164270、NM_002875、NM_133487、XM_006720626、XM_011521857、XM_011521858、XM_011521859、XM_011521860、XM_011521861
	NM_011234、NR_156017
	NP_001157741、NP_001157742、NP_002866、NP_597994、XP_006720689、XP_011520159、XP_011520160、XP_011520161、XP_011520162、XP_011520163、XP_011520164
	NP_035364
	維基數據

Rad51是真核生物體內的一種蛋白質，与原核生物的RecA同源，是一种高度保守的蛋白，從酵母菌到人類之間的變異不大。人類的Rad51含有339個氨基酸，於同源重組中扮演主要角色，參與搜尋同源部位與DNA的配對過程。

人類的Rad51的基因位於第15號染色體。包括此基因在內，哺乳類共有七種類似recA的基因，包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1[7]。

參考文獻

.
GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027323 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
页面存档备份，存于 Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004
Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

Galkin,V .E. et al. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)

Pellegrini, L. et al. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)

外部連結

MeSH（醫學主題詞）上面的RAD51+Protein（美式英语）

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000027323 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] 页面存档备份，存于 Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004

[7] Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)