STAT2

Signal transducer and activator of transcription 2, 113kDa; 信号转导及转录激活蛋白2，113千道尔顿
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2KA4
标识
代号	STAT2; ISGF-3; P113; STAT113
扩展标识	遗传学：600556 鼠基因：103039 同源基因：3952 GeneCards: STAT2 Gene
基因本体论描述
分子功能	· DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · calcium ion binding; · protein binding;
细胞成分	· nucleoplasm; · cytoplasm; · cytosol; · plasma membrane;
生物过程	· transcription, DNA-dependent; · regulation of transcription from RNA polymerase II promoter; · JAK-STAT cascade; · virus-host interaction; · cytokine-mediated signaling pathway; · defense response to virus; · type I interferon-mediated signaling pathway; · regulation of type I interferon-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

信号转导及转录激活蛋白2（英語：）是一種由人类基因STAT2 所表达的蛋白质[1][2]。

相互作用

STAT2能与MED14[3]、CREB结合蛋白[4]、SMARCA4[5]、STAT1[6][7][8]、IFNAR2[9][10] IFNAR1[9][11][12]和ISGF3G[13][14]相互作用。

参考文献

Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr. . Nucleic Acids Res. Apr 1995, 23 (3): 459–63. PMC 306697. PMID 7885841. doi:10.1093/nar/23.3.459.
.
Lau, Joe F; Nusinzon Inna, Burakov Darya, Freedman Leonard P, Horvath Curt M. . Mol. Cell. Biol. (United States). Jan 2003, 23 (2): 620–8. ISSN 0270-7306. PMC 151539. PMID 12509459. doi:10.1128/MCB.23.2.620-628.2003.
Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M. . Nature (ENGLAND). Sep 1996, 383 (6598): 344–7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0.
Huang, Mei; Qian Feng, Hu Yuanyu, Ang Chengeng, Li Zhong, Wen Zilong. . Nat. Cell Biol. (England). Oct 2002, 4 (10): 774–81. ISSN 1465-7392. PMID 12244326. doi:10.1038/ncb855.
Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. . J. Biol. Chem. (UNITED STATES). Mar 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.
Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. . J. Biol. Chem. (UNITED STATES). Aug 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.
Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. . J. Biol. Chem. (United States). Aug 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.
Li, X; Leung S, Kerr I M, Stark G R. . Mol. Cell. Biol. (UNITED STATES). Apr 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453.
Nguyen, Vinh-Phúc; Saleh Abu Z M, Arch Allison E, Yan Hai, Piazza Flavia, Kim John, Krolewski John J. . J. Biol. Chem. (United States). Mar 2002, 277 (12): 9713–21. ISSN 0021-9258. PMID 11786546. doi:10.1074/jbc.M111161200.
Uddin, S; Chamdin A, Platanias L C. . J. Biol. Chem. (UNITED STATES). Oct 1995, 270 (42): 24627–30. ISSN 0021-9258. PMID 7559568. doi:10.1074/jbc.270.42.24627.
Yan, H; Krishnan K, Greenlund A C, Gupta S, Lim J T, Schreiber R D, Schindler C W, Krolewski J J. . EMBO J. (ENGLAND). Mar 1996, 15 (5): 1064–74. ISSN 0261-4189. PMC 450004. PMID 8605876.
Horvath, C M; Stark G R, Kerr I M, Darnell J E. . Mol. Cell. Biol. (UNITED STATES). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351.
Martinez-Moczygemba, M; Gutch M J, French D L, Reich N C. . J. Biol. Chem. (UNITED STATES). Aug 1997, 272 (32): 20070–6. ISSN 0021-9258. PMID 9242679. doi:10.1074/jbc.272.32.20070.

延伸阅读

Cebulla CM, Miller DM, Sedmak DD. . Intervirology. 2000, 42 (5–6): 325–30. PMID 10702714. doi:10.1159/000053968.
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. . Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
Fu XY, Schindler C, Improta T; 等. . Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (16): 7840–3. PMC 49807. PMID 1502204. doi:10.1073/pnas.89.16.7840.
Uddin S, Chamdin A, Platanias LC. . J. Biol. Chem. 1995, 270 (42): 24627–30. PMID 7559568. doi:10.1074/jbc.270.42.24627.
Marrero MB, Schieffer B, Paxton WG; 等. . Nature. 1995, 375 (6528): 247–50. PMID 7746328. doi:10.1038/375247a0.
Sugiyama T, Nishio Y, Kishimoto T, Akira S. . FEBS Lett. 1996, 381 (3): 191–4. PMID 8601453. doi:10.1016/0014-5793(96)00121-4.
Yan H, Krishnan K, Greenlund AC; 等. . EMBO J. 1996, 15 (5): 1064–74. PMC 450004. PMID 8605876.
Gupta S, Yan H, Wong LH; 等. . EMBO J. 1996, 15 (5): 1075–84. PMC 450005. PMID 8605877.
Li X, Leung S, Qureshi S; 等. . J. Biol. Chem. 1996, 271 (10): 5790–4. PMID 8621447. doi:10.1074/jbc.271.10.5790.
Bhattacharya S, Eckner R, Grossman S; 等. . Nature. 1996, 383 (6598): 344–7. PMID 8848048. doi:10.1038/383344a0.
Horvath CM, Stark GR, Kerr IM, Darnell JE. . Mol. Cell. Biol. 1997, 16 (12): 6957–64. PMC 231699. PMID 8943351.
Bluyssen HA, Levy DE. . J. Biol. Chem. 1997, 272 (7): 4600–5. PMID 9020188. doi:10.1074/jbc.272.7.4600.
Li X, Leung S, Kerr IM, Stark GR. . Mol. Cell. Biol. 1997, 17 (4): 2048–56. PMC 232052. PMID 9121453.
Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. . J. Biol. Chem. 1997, 272 (32): 20070–6. PMID 9242679. doi:10.1074/jbc.272.32.20070.
Mowen K, David M. . J. Biol. Chem. 1998, 273 (46): 30073–6. PMID 9804758. doi:10.1074/jbc.273.46.30073.
Dumler I, Kopmann A, Wagner K; 等. . J. Biol. Chem. 1999, 274 (34): 24059–65. PMID 10446176. doi:10.1074/jbc.274.34.24059.
Paulson M, Pisharody S, Pan L; 等. . J. Biol. Chem. 1999, 274 (36): 25343–9. PMID 10464260. doi:10.1074/jbc.274.36.25343.
Gupta S, Jiang M, Pernis AB. . J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A; 等. . FASEB J. 1999, 13 (13): 1699–710. PMID 10506573.

外部链接

MeSH（醫學主題詞）上面的STAT2+Transcription+Factor（美式英语）
FactorBook STAT2

STAT2引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[pmid7885841-1] Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr. . Nucleic Acids Res. Apr 1995, 23 (3): 459–63. PMC 306697. PMID 7885841. doi:10.1093/nar/23.3.459.

[entrez-2] .

[pmid12509459-3] Lau, Joe F; Nusinzon Inna, Burakov Darya, Freedman Leonard P, Horvath Curt M. . Mol. Cell. Biol. (United States). Jan 2003, 23 (2): 620–8. ISSN 0270-7306. PMC 151539. PMID 12509459. doi:10.1128/MCB.23.2.620-628.2003.

[pmid8848048-4] Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M. . Nature (ENGLAND). Sep 1996, 383 (6598): 344–7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0.

[pmid12244326-5] Huang, Mei; Qian Feng, Hu Yuanyu, Ang Chengeng, Li Zhong, Wen Zilong. . Nat. Cell Biol. (England). Oct 2002, 4 (10): 774–81. ISSN 1465-7392. PMID 12244326. doi:10.1038/ncb855.

[pmid8621447-6] Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. . J. Biol. Chem. (UNITED STATES). Mar 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.

[pmid10446176-7] Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. . J. Biol. Chem. (UNITED STATES). Aug 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.

[pmid12048190-8] Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. . J. Biol. Chem. (United States). Aug 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.

[pmid9121453-9] Li, X; Leung S, Kerr I M, Stark G R. . Mol. Cell. Biol. (UNITED STATES). Apr 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453.

[pmid11786546-10] Nguyen, Vinh-Phúc; Saleh Abu Z M, Arch Allison E, Yan Hai, Piazza Flavia, Kim John, Krolewski John J. . J. Biol. Chem. (United States). Mar 2002, 277 (12): 9713–21. ISSN 0021-9258. PMID 11786546. doi:10.1074/jbc.M111161200.

[pmid7559568-11] Uddin, S; Chamdin A, Platanias L C. . J. Biol. Chem. (UNITED STATES). Oct 1995, 270 (42): 24627–30. ISSN 0021-9258. PMID 7559568. doi:10.1074/jbc.270.42.24627.

[pmid8605876-12] Yan, H; Krishnan K, Greenlund A C, Gupta S, Lim J T, Schreiber R D, Schindler C W, Krolewski J J. . EMBO J. (ENGLAND). Mar 1996, 15 (5): 1064–74. ISSN 0261-4189. PMC 450004. PMID 8605876.

[pmid8943351-13] Horvath, C M; Stark G R, Kerr I M, Darnell J E. . Mol. Cell. Biol. (UNITED STATES). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351.

[pmid9242679-14] Martinez-Moczygemba, M; Gutch M J, French D L, Reich N C. . J. Biol. Chem. (UNITED STATES). Aug 1997, 272 (32): 20070–6. ISSN 0021-9258. PMID 9242679. doi:10.1074/jbc.272.32.20070.