STAT1

Signal transducer and activator of transcription 1, 91kDa; 信号转导及转录激活蛋白1，91千道尔顿
	STAT1 bound to DNA
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1BF5, 1YVL, 2KA6
标识
代号	STAT1; CANDF7; ISGF-3; STAT91
扩展标识	遗传学：600555 鼠基因：103063 同源基因：21428 ChEMBL: 6101 GeneCards: STAT1 Gene
基因本体论描述
分子功能	· RNA polymerase II core promoter proximal region sequence-specific DNA binding; · RNA polymerase II core promoter sequence-specific DNA binding; · RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; · double-stranded DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · tumor necrosis factor receptor binding; · calcium ion binding; · protein binding; · enzyme binding; · protein homodimerization activity;
细胞成分	· nuclear chromatin; · nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · cytosol; · axon; · dendrite;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · negative regulation of endothelial cell proliferation; · positive regulation of mesenchymal cell proliferation; · negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; · regulation of transcription from RNA polymerase II promoter; · induction of apoptosis; · JAK-STAT cascade; · blood circulation; · negative regulation of angiogenesis; · virus-host interaction; · cytokine-mediated signaling pathway; · lipopolysaccharide-mediated signaling pathway; · tumor necrosis factor-mediated signaling pathway; · response to cytokine stimulus; · cellular response to interferon-beta; · regulation of apoptotic process; · negative regulation of I-kappaB kinase/NF-kappaB cascade; · response to exogenous dsRNA; · response to peptide hormone stimulus; · endothelial cell migration; · positive regulation of transcription, DNA-dependent; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of smooth muscle cell proliferation; · response to cAMP; · defense response to virus; · interferon-gamma-mediated signaling pathway; · regulation of interferon-gamma-mediated signaling pathway; · type I interferon-mediated signaling pathway; · regulation of type I interferon-mediated signaling pathway; · JAK-STAT cascade involved in growth hormone signaling pathway; · renal tubule development; · metanephric mesenchymal cell proliferation involved in metanephros development; · metanephric mesenchymal cell differentiation; · negative regulation of metanephric nephron tubule epithelial cell differentiation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上[1]。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[2]

相互作用

STAT1能与下列蛋白质发生相互作用：

蛋白激酶R[3][4]
Src[5][6]
IRF1[7]
STAT3[8][9][10]
MCM5[11][12]
STAT2[13][14][15]
CD117[16]
Fanconi anemia, complementation group C[17][18][19]
CREB结合蛋白[20]
白介素27受体α亚基[21]
PIAS1[22]
BRCA1[23]
表皮生长因子受体[5][10]
PTK2[24]
Mammalian target of rapamycin[25]
IFNAR2[26][27]
PRKCD[25]
TRADD[28]
C-jun[29]
Calcitriol receptor[30]
ISGF3G[31]
GNB2L1[27][32]

参考文献

Michael G. Katze; Yupeng He & Michael Gale; 等. . Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 已忽略未知参数|author-separator= (帮助)
Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. . Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871.
Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E. . EMBO J. (ENGLAND). March 1997, 16 (6): 1291–304. ISSN 0261-4189. PMC 1169727. PMID 9135145. doi:10.1093/emboj/16.6.1291.
Wong, A H; Durbin J E, Li S, Dever T E, Decker T, Koromilas A E. . J. Biol. Chem. (United States). April 2001, 276 (17): 13727–37. ISSN 0021-9258. PMID 11278865. doi:10.1074/jbc.M011240200.
Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E. . J. Biol. Chem. (United States). June 1999, 274 (24): 17209–18. ISSN 0021-9258. PMID 10358079. doi:10.1074/jbc.274.24.17209.
Cirri, P; Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G. . Biochem. Biophys. Res. Commun. (United States). October 1997, 239 (2): 493–7. ISSN 0006-291X. PMID 9344858. doi:10.1006/bbrc.1997.7493.
Chatterjee-Kishore, M; van Den Akker F, Stark G R. . J. Biol. Chem. (United States). July 2000, 275 (27): 20406–11. ISSN 0021-9258. PMID 10764778. doi:10.1074/jbc.M001861200.
Gunaje, J J; Bhat G J. . Biochem. Biophys. Res. Commun. (United States). October 2001, 288 (1): 252–7. ISSN 0006-291X. PMID 11594781. doi:10.1006/bbrc.2001.5759.
Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F. . Eur. J. Haematol. (Denmark). August 2001, 67 (2): 63–71. ISSN 0902-4441. PMID 11722592.
Xia, Ling; Wang Lijuan, Chung Alicia S, Ivanov Stanimir S, Ling Mike Y, Dragoi Ana M, Platt Adam, Gilmer Tona M, Fu Xin-Yuan, Chin Y Eugene. . J. Biol. Chem. (United States). August 2002, 277 (34): 30716–23. ISSN 0021-9258. PMID 12070153. doi:10.1074/jbc.M202823200.
Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E. . EMBO J. (ENGLAND). Dec 1998, 17 (23): 6963–71. ISSN 0261-4189. PMC 1171044. PMID 9843502. doi:10.1093/emboj/17.23.6963.
DaFonseca, C J; Shu F, Zhang J J. . Proc. Natl. Acad. Sci. U.S.A. (United States). March 2001, 98 (6): 3034–9. ISSN 0027-8424. PMC 30602. PMID 11248027. doi:10.1073/pnas.061487598.
Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. . J. Biol. Chem. (United States). March 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.
Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. . J. Biol. Chem. (United States). August 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.
Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. . J. Biol. Chem. (United States). August 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.
Deberry, C; Mou S, Linnekin D. . Biochem. J. (ENGLAND). October 1997, 327 (1): 73–80. ISSN 0264-6021. PMC 1218765. PMID 9355737.
Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. . Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895. PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000.
Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J. . Exp. Cell Res. (United States). October 2003, 289 (2): 211–21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.
Pang, Q; Christianson T A, Keeble W, Diaz J, Faulkner G R, Reifsteck C, Olson S, Bagby G C. . Blood (United States). September 2001, 98 (5): 1392–401. ISSN 0006-4971. PMID 11520787. doi:10.1182/blood.V98.5.1392.
Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E. . Proc. Natl. Acad. Sci. U.S.A. (United States). Dec 1996, 93 (26): 15092–6. ISSN 0027-8424. PMC 26361. PMID 8986769. doi:10.1073/pnas.93.26.15092.
Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki. . J. Immunol. (United States). May 2003, 170 (10): 4886–90. ISSN 0022-1767. PMID 12734330.
Liao, J; Fu Y, Shuai K. . Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5267–72. ISSN 0027-8424. PMC 25817. PMID 10805787. doi:10.1073/pnas.97.10.5267.
Ouchi, T; Lee S W, Ouchi M, Aaronson S A, Horvath C M. . Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5208–13. ISSN 0027-8424. PMC 25807. PMID 10792030. doi:10.1073/pnas.080469697.
Xie, B; Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y. . J. Biol. Chem. (United States). June 2001, 276 (22): 19512–23. ISSN 0021-9258. PMID 11278462. doi:10.1074/jbc.M009063200.
Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel. . J. Biol. Chem. (United States). September 2003, 278 (36): 33637–44. ISSN 0021-9258. PMID 12807916. doi:10.1074/jbc.M301053200.
Li, X; Leung S, Kerr I M, Stark G R. . Mol. Cell. Biol. (United States). April 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453.
Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O. . J. Biol. Chem. (United States). June 2001, 276 (25): 22948–53. ISSN 0021-9258. PMID 11301323. doi:10.1074/jbc.M100087200.
Wang, Y; Wu T R, Cai S, Welte T, Chin Y E. . Mol. Cell. Biol. (United States). July 2000, 20 (13): 4505–12. ISSN 0270-7306. PMC 85828. PMID 10848577. doi:10.1128/MCB.20.13.4505-4512.2000.
Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E. . Mol. Cell. Biol. (United States). October 1999, 19 (10): 7138–46. ISSN 0270-7306. PMC 84707. PMID 10490649.
Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S. . Mol. Cell. Biol. (United States). April 2002, 22 (8): 2777–87. ISSN 0270-7306. PMC 133712. PMID 11909970. doi:10.1128/MCB.22.8.2777-2787.2002.
Horvath, C M; Stark G R, Kerr I M, Darnell J E. . Mol. Cell. Biol. (United States). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351.
Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R. . J. Immunol. (United States). September 2003, 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.

延伸阅读

Cebulla CM, Miller DM, Sedmak DD. . Intervirology. 2000, 42 (5–6): 325–30. PMID 10702714. doi:10.1159/000053968.
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. . Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
Joseph AM, Kumar M, Mitra D. . Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.

外部链接

FactorBook STAT1

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Michael G. Katze; Yupeng He & Michael Gale; 等. . Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 已忽略未知参数|author-separator= (帮助)

[2] Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. . Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871.

[pmid9135145-3] Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E. . EMBO J. (ENGLAND). March 1997, 16 (6): 1291–304. ISSN 0261-4189. PMC 1169727. PMID 9135145. doi:10.1093/emboj/16.6.1291.

[pmid11278865-4] Wong, A H; Durbin J E, Li S, Dever T E, Decker T, Koromilas A E. . J. Biol. Chem. (United States). April 2001, 276 (17): 13727–37. ISSN 0021-9258. PMID 11278865. doi:10.1074/jbc.M011240200.

[pmid10358079-5] Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E. . J. Biol. Chem. (United States). June 1999, 274 (24): 17209–18. ISSN 0021-9258. PMID 10358079. doi:10.1074/jbc.274.24.17209.

[pmid9344858-6] Cirri, P; Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G. . Biochem. Biophys. Res. Commun. (United States). October 1997, 239 (2): 493–7. ISSN 0006-291X. PMID 9344858. doi:10.1006/bbrc.1997.7493.

[pmid10764778-7] Chatterjee-Kishore, M; van Den Akker F, Stark G R. . J. Biol. Chem. (United States). July 2000, 275 (27): 20406–11. ISSN 0021-9258. PMID 10764778. doi:10.1074/jbc.M001861200.

[pmid11594781-8] Gunaje, J J; Bhat G J. . Biochem. Biophys. Res. Commun. (United States). October 2001, 288 (1): 252–7. ISSN 0006-291X. PMID 11594781. doi:10.1006/bbrc.2001.5759.

[pmid11722592-9] Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F. . Eur. J. Haematol. (Denmark). August 2001, 67 (2): 63–71. ISSN 0902-4441. PMID 11722592.

[pmid12070153-10] Xia, Ling; Wang Lijuan, Chung Alicia S, Ivanov Stanimir S, Ling Mike Y, Dragoi Ana M, Platt Adam, Gilmer Tona M, Fu Xin-Yuan, Chin Y Eugene. . J. Biol. Chem. (United States). August 2002, 277 (34): 30716–23. ISSN 0021-9258. PMID 12070153. doi:10.1074/jbc.M202823200.

[pmid9843502-11] Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E. . EMBO J. (ENGLAND). Dec 1998, 17 (23): 6963–71. ISSN 0261-4189. PMC 1171044. PMID 9843502. doi:10.1093/emboj/17.23.6963.

[pmid11248027-12] DaFonseca, C J; Shu F, Zhang J J. . Proc. Natl. Acad. Sci. U.S.A. (United States). March 2001, 98 (6): 3034–9. ISSN 0027-8424. PMC 30602. PMID 11248027. doi:10.1073/pnas.061487598.

[pmid8621447-13] Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. . J. Biol. Chem. (United States). March 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.

[pmid10446176-14] Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. . J. Biol. Chem. (United States). August 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.

[pmid12048190-15] Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. . J. Biol. Chem. (United States). August 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.

[pmid9355737-16] Deberry, C; Mou S, Linnekin D. . Biochem. J. (ENGLAND). October 1997, 327 (1): 73–80. ISSN 0264-6021. PMC 1218765. PMID 9355737.

[pmid10848598-17] Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. . Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895. PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000.

[pmid14499622-18] Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J. . Exp. Cell Res. (United States). October 2003, 289 (2): 211–21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.

[pmid11520787-19] Pang, Q; Christianson T A, Keeble W, Diaz J, Faulkner G R, Reifsteck C, Olson S, Bagby G C. . Blood (United States). September 2001, 98 (5): 1392–401. ISSN 0006-4971. PMID 11520787. doi:10.1182/blood.V98.5.1392.

[pmid8986769-20] Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E. . Proc. Natl. Acad. Sci. U.S.A. (United States). Dec 1996, 93 (26): 15092–6. ISSN 0027-8424. PMC 26361. PMID 8986769. doi:10.1073/pnas.93.26.15092.

[pmid12734330-21] Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki. . J. Immunol. (United States). May 2003, 170 (10): 4886–90. ISSN 0022-1767. PMID 12734330.

[pmid10805787-22] Liao, J; Fu Y, Shuai K. . Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5267–72. ISSN 0027-8424. PMC 25817. PMID 10805787. doi:10.1073/pnas.97.10.5267.

[pmid10792030-23] Ouchi, T; Lee S W, Ouchi M, Aaronson S A, Horvath C M. . Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5208–13. ISSN 0027-8424. PMC 25807. PMID 10792030. doi:10.1073/pnas.080469697.

[pmid11278462-24] Xie, B; Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y. . J. Biol. Chem. (United States). June 2001, 276 (22): 19512–23. ISSN 0021-9258. PMID 11278462. doi:10.1074/jbc.M009063200.

[pmid12807916-25] Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel. . J. Biol. Chem. (United States). September 2003, 278 (36): 33637–44. ISSN 0021-9258. PMID 12807916. doi:10.1074/jbc.M301053200.

[pmid9121453-26] Li, X; Leung S, Kerr I M, Stark G R. . Mol. Cell. Biol. (United States). April 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453.

[pmid11301323-27] Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O. . J. Biol. Chem. (United States). June 2001, 276 (25): 22948–53. ISSN 0021-9258. PMID 11301323. doi:10.1074/jbc.M100087200.

[pmid10848577-28] Wang, Y; Wu T R, Cai S, Welte T, Chin Y E. . Mol. Cell. Biol. (United States). July 2000, 20 (13): 4505–12. ISSN 0270-7306. PMC 85828. PMID 10848577. doi:10.1128/MCB.20.13.4505-4512.2000.

[pmid10490649-29] Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E. . Mol. Cell. Biol. (United States). October 1999, 19 (10): 7138–46. ISSN 0270-7306. PMC 84707. PMID 10490649.

[pmid11909970-30] Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S. . Mol. Cell. Biol. (United States). April 2002, 22 (8): 2777–87. ISSN 0270-7306. PMC 133712. PMID 11909970. doi:10.1128/MCB.22.8.2777-2787.2002.

[pmid8943351-31] Horvath, C M; Stark G R, Kerr I M, Darnell J E. . Mol. Cell. Biol. (United States). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351.

[pmid12960323-32] Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R. . J. Immunol. (United States). September 2003, 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.