VCAM-1
VCAM-1(Vascular cell adhesion protein 1(I型血管細胞黏附蛋白)),又稱CD106,是一種細胞黏附蛋白,在人體內由VCAM-1基因編碼,屬於一種唾液酸糖蛋白[5]。
功能與分佈
VCAM-1參與淋巴細胞—內皮細胞間黏附過程和細胞間信號識別過程,能在免疫應答中促進淋巴細胞向炎症區遷移[7]。淋巴細胞、軟骨細胞等細胞中都含有VCAM-1,血管內皮細胞在受到細胞因子刺激後也會表達VCAM-1蛋白[6][8]。一些間充質幹細胞亞群細胞表面表達CD106(VCAM-1)[9]。
參考
- GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017
- . National Center for Biotechnology Information, U.S. National Library of Medicine.
- . National Center for Biotechnology Information, U.S. National Library of Medicine.
- Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. . Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.
- .
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- Kienzle G.; von Kempis J. . Arthritis Rheum. 1998 Jul;41(7):1296-305.
- ZX Yang; 等. . PLoS One. 2013;8(3):e59354.
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