地屈孕酮

地屈孕酮英語:,商品名为Duphaston等)是一种黄体制剂药物,用于治疗一系列疾病,包括妊娠期的习惯性流产黃體期缺陷(LPD)造成的功能失调性子宫出血不孕經痛子宮內膜異位症,继发性閉經月经周期紊乱经前综合症,是激素替代療法的选用药物之一[2],通常由口服给药[2]

地屈孕酮
系统(IUPAC)命名名称
(8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
临床数据
商品名Duphaston, others
Drugs.com国际药品名称
给药途径By mouth
合法狀態
合法状态
  • 处方药(-only)
药代动力学数据
生物利用度28%[1]
蛋白结合度? (probably至albumin)[1][2]
代谢Hepatic: AKR1C1, AKR1C3, CYP3A4[3][4]
代謝產物20α-DHD (exclusively via AKR1C1 and AKRC13)[4]
生物半衰期Parent: 5–7 hours[5]
Metabolite: 14–17 hours[5]
排泄Urine
识别
CAS注册号152-62-5  
ATC代码G03DB01
PubChemCID 9051
DrugBankDB00378 
ChemSpider8699 
UNII90I02KLE8K 
KEGGD01217 
ChEBICHEBI:31527 
其他名称Isopregnenone; Dehydroprogesterone; Didrogesteron; 6-Dehydroretroprogesterone; 9β,10α-Pregna-4,6-diene-3,20-dione; NSC-92336[6][7]
化学
化学式C21H28O2
摩尔质量312.446 g/mol
物理性质
熔点144 °C(291 °F)
沸点463 °C(865 °F)
水溶液Insoluble mg/mL (20 °C)

参考文献

  1. ((Howard JA Carp, MB, BS, FRCOG)). . Springer. 9 April 2015: 33, 38. ISBN 978-3-319-14385-9. 温哥华格式错误 (帮助)
  2. Kuhl H. . Climacteric. 2005,. 8 Suppl 1: 3–63. PMID 16112947. doi:10.1080/13697130500148875.
  3. Olbrich, Matthias; Weigl, Kevin; Kahler, Elke; Mihara, Katsuhiro. . Xenobiotica. 2016, 46 (10): 868–874. ISSN 0049-8254. PMID 26796435. doi:10.3109/00498254.2015.1134852.
  4. Beranič, N.; Gobec, S.; Rižner, T. Lanišnik. . Chemico-Biological Interactions. 2011, 191 (1–3): 227–233. ISSN 0009-2797. PMID 21182831. doi:10.1016/j.cbi.2010.12.012.
  5. Bińkowska, Małgorzata; Woroń, Jarosław. . Menopausal Review. 2015, 14 (2): 134–143. ISSN 1643-8876. PMC 4498031. PMID 26327902. doi:10.5114/pm.2015.52154.
  6. J. Elks. . Springer. 14 November 2014: 474– [2019-06-09]. ISBN 978-1-4757-2085-3. (原始内容存档于2020-08-03).
  7. . Taylor & Francis. January 2000: 378–. ISBN 978-3-88763-075-1.
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