孕三烯酮

孕三烯酮英語:)是一种用于治疗子宮內膜異位症的药物[2][3],也用于治疗子宮肌瘤經血過多以及进行生育控制[1]。孕三烯酮通常单独使用,不与其他药物联合使用[4],可由口服给药阴道内给药[1]

孕三烯酮
系统(IUPAC)命名名称
(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
临床数据
商品名Dimetriose, Dimetrose, Nemestran, others
Drugs.com国际药品名称
妊娠分级
  • X
给药途径By mouth, vaginal[1]
药代动力学数据
蛋白结合度To albumin[1]
代谢Liver (hydroxylation)[1]
生物半衰期27.3 hours[1]
排泄Urine and bile[1]
识别
CAS注册号16320-04-0  
ATC代码G03XA02
PubChemCID 27812
DrugBankDB11619 
ChemSpider25877 
UNII1421533RCM 
KEGGD04317 
ChEBICHEBI:89642
ChEMBLCHEMBL1868702
其他名称Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one
化学
化学式C21H24O2
摩尔质量308.41 g/mol

参考文献

  1. Eric J. Thomas; John Rock. . Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2.
  2. Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
  3. Dr. Ian Morton; I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9.

延伸阅读

  • Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. . Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活跃 2018-10-13).
  • Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
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