孕三烯酮
孕三烯酮(英語:)是一种用于治疗子宮內膜異位症的药物[2][3],也用于治疗子宮肌瘤、經血過多以及进行生育控制[1]。孕三烯酮通常单独使用,不与其他药物联合使用[4],可由口服给药或阴道内给药[1]。
系统(IUPAC)命名名称 | |
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(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | |
临床数据 | |
商品名 | Dimetriose, Dimetrose, Nemestran, others |
Drugs.com | 国际药品名称 |
妊娠分级 |
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给药途径 | By mouth, vaginal[1] |
药代动力学数据 | |
蛋白结合度 | To albumin[1] |
代谢 | Liver (hydroxylation)[1] |
生物半衰期 | 27.3 hours[1] |
排泄 | Urine and bile[1] |
识别 | |
CAS注册号 | 16320-04-0 |
ATC代码 | G03XA02 |
PubChem | CID 27812 |
DrugBank | DB11619 |
ChemSpider | 25877 |
UNII | 1421533RCM |
KEGG | D04317 |
ChEBI | CHEBI:89642 |
ChEMBL | CHEMBL1868702 |
其他名称 | Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one |
化学 | |
化学式 | C21H24O2 |
摩尔质量 | 308.41 g/mol |
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参考文献
- Eric J. Thomas; John Rock. . Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2.
- Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
- Dr. Ian Morton; I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9.
延伸阅读
- Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. . Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活跃 2018-10-13).
- Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
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