SOCS3
细胞因子信号传导抑制因子3(SOCS3或 SOCS-3)是一种在人体内由 SOCS3基因编码的蛋白。[5][6] 该基因编码 STAT- 诱导的 STAT 抑制子(SSI),也可称为细胞因子信号转导(SOCS)家族抑制子,的一个成员。 SSI 家族成员是可由细胞因子诱导的细胞因子信号转导负调节因子。
功能
SOCS3基因的表达可由多种细胞因子的诱导,包括 IL-6,IL-10,干扰素-γ(IFN-γ)。
在 IL-6,Epo,GCSF 和瘦素的信号传导中,已发现SOCS3在各自的细胞因子受体上的结合对 SOCS3的抑制功能而言是至关重要的。
SOCS3的过表达会抑制脂肪组织和肝脏胰岛素信号转导,但对肌肉则不然。[7] 但是在小鼠骨骼肌中敲除 SOCS3可以保护小鼠免于肥胖相关的胰岛素抵抗。[7]
由于神经酰胺合成的增加,SOCS3会增加瘦素抵抗和胰岛素抵抗。[8] 因此,研究已表明去除 SOCS 基因可以预防肥胖症患者的胰岛素抵抗[7]
对该小鼠中基因的同源基因的研究表明,该基因在胎儿肝脏造血和胎盘发育的负调控中发挥作用。[9]
SOCS3蛋白能与JAK2结合,抑制其活性。
相互作用
已经证明 SOCS3可以与下列物质相互作用:
参见
- SOCS
- JAK-STAT信号通路
参考文献
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扩展阅读
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