TRIM21
三分模體包含蛋白質21(Tripartite motif-containing protein 21,縮寫爲TRIM21),亦作E3泛素化蛋白質連接酶TRIM21(E3 ubiquitin-protein ligase TRIM21),係一種由人類TRIM21基因編碼的蛋白質[2][3]。人們已經發現了該蛋白質的可變剪切變體,但目前僅查明了其中一種在完整狀態下的性質。大部分人類組織都表達此種蛋白[4]。
功能
TRIM21爲一種細胞內抗體介導蛋白水解途徑的細胞內抗體效應子。它會與標記感染細胞的無包膜病毒體的抗體上的免疫球蛋白G和免疫球蛋白M相連。隨後,其自身發生泛素化或一個輔助因子發生泛素化。其後,TRIM21會負責引導病毒體到有蛋白酶的位置。抗體和病毒的衣殼會被蛋白酶水解,但TRIM21卻不會[4]。
TRIM21爲RoSSA核糖核蛋白的一個組成成分。RoSSA還含有一條單多肽鏈以及一條小分子RNA(這條RNA有4種)。細胞質和細胞核中均有RoSSA粒子[3]。
參考
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- 黄堃. . 新華網. [2016-02-09]. (原始内容存档于2016-07-03).
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