甘草次酸

**甘草次酸**
系统（IUPAC）命名名称
	(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid; OR; (1R,2R,5S,8S,10R,14R,15S,18S,20R)-18-hydroxy-1,2,5,8,15,19,19-heptamethyl-13-oxopentacyclo[12.8.0.02,11.05,10.015,20]docos-11-ene-8-carboxylic acid
临床数据
商品名	Arthrodont, PruClair
Drugs.com	国际药品名称
给药途径	Oral, topical
合法狀態
合法状态	US: 处方药（℞-only） ;
识别
CAS注册号	471-53-4
ATC代码	D03AX10
PubChem	CID 10114
ChemSpider	9710
ChEBI	CHEBI:30853
ChEMBL	CHEMBL230006
化学
化学式	C30H46O4
摩尔质量	470.6838
	SMILES O=C(O)[C@]5(C)C[C@H]4/C3=C/C(=O)[C@H]1[C@](CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C)(C)[C@]3(C)CC[C@@]4(C)CC5;
	InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1; Key:MPDGHEJMBKOTSU-YKLVYJNSSA-N;

甘草次酸（glycyrrhetinic acid，或glycyrrhetic acid，也叫Enoxolone）是一种五环三萜物质，由草药光果甘草的甘草酸水解得到故而得名。甘草次酸可以看作是β-香树脂醇（齐墩果烷型）的衍生物，从而作为甘草酸的糖苷配基。甘草次酸常作为香料使用，也用来掩盖芦荟和奎寧等药物的苦味。[1][2][3][4][5]

另见

Chandler, RF. . Canadian Pharmaceutical Journal. 1985, (118): 420–4.
Badam, L.; Amagaya, S.; Pollard, B. . J. Community Dis. 1997, 29: 91–99.
Fuji, H.Y.; Tian, J.; Luka, C. . Bull. Chin. Mater. Med. 1986, 11: 238–241.
Guo, N.; Takechi, M.; Uno, C. . J. Pharm. Pharmacol. 1991, 13 (5): 380–383. PMID 1839259.
Salari, M. H.; Sohrabi, N.; Kadkhoda, Z.; and Khalili, M. B.; capnophilic bacteria isolated from specimens of periodontitis patients. . Iran. Biomed. J. 2003, 7: 39–42.

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