甲磺酸赖氨酸安非他命

甲磺酸赖氨酸安非他命英語:),名字来源为“離胺酸-右旋安非他命”,是 中樞神經系統(CNS)右旋安非他命刺激剂前体药物,一种安非他命类苯乙胺衍生物,用于治疗注意力不足過動症(ADHD)和過胖暴食症[4][5]

甲磺酸赖氨酸安非他命
系统(IUPAC)命名名称
(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
临床数据
Drugs.comMonograph
MedlinePlusa607047
医疗法规
妊娠分级
  • AU: B3
  • US: C (不排除有风险的可能)
依赖性身体依赖: 无
精神依赖: 中等
成瘾性中等
给药途径口服(胶囊
合法狀態
合法状态
药代动力学数据
生物利用度96.4%[1]
代谢起初由红血球水解
余下的代谢过程同安非他命#药物代谢动力学
開始出現藥效2小时[2][3]
生物半衰期≤1小时(前体药物分子)
9至11小时(右旋安非他命)
作用时间12 hours[2][3]
排泄肾脏:约2%
识别
CAS注册号608137-32-2  [IUPHAR]
ATC代码N06BA12
PubChemCID 11597698
IUPHAR/BPS7213
DrugBankDB01255 
ChemSpider9772458 [Chemspider]
UNIIH645GUL8KJ 
ChEMBLCHEMBL1201222 
其他名称Vyvanse
化学
化学式C15H25N3O
摩尔质量263.378 g/mol
30毫克Vyvanse胶囊

参考资料

  1. (PDF). Shire Pharmaceuticals Contracts Limited: 14. [2014-08-23]. (原始内容存档 (PDF)于2014-08-26).
  2. Millichap JG. . Millichap JG (编). 2nd. New York, USA: Springer. 2010: 112. ISBN 9781441913968.
    Table 9.2 Dextroamphetamine formulations of stimulant medication
    Dexedrine [Peak:2–3 h] [Duration:5–6 h] ...
    Adderall [Peak:2–3 h] [Duration:5–7 h]
    Dexedrine spansules [Peak:7–8 h] [Duration:12 h] ...
    Adderall XR [Peak:7–8 h] [Duration:12 h]
    Vyvanse [Peak:3–4 h] [Duration:12 h]
  3. Brams M, Mao AR, Doyle RL. . Postgrad. Med. September 2008, 120 (3): 69–88. PMID 18824827. doi:10.3810/pgm.2008.09.1909. Onset of efficacy was earliest for d-MPH-ER at 0.5 hours, followed by d, l-MPH-LA at 1 to 2 hours, MCD at 1.5 hours, d, l-MPH-OR at 1 to 2 hours, MAS-XR at 1.5 to 2 hours, MTS at 2 hours, and LDX at approximately 2 hours. ... MAS-XR, and LDX have a long duration of action at 12 hours postdose
  4. (PDF). United States Food and Drug Administration. Shire US Inc. January 2015 [2015-02-24]. (原始内容存档 (PDF)于2015-02-25).
  5. Heal DJ, Smith SL, Gosden J, Nutt DJ. . J. Psychopharmacol. June 2013, 27 (6): 479–496. PMC 3666194. PMID 23539642. doi:10.1177/0269881113482532.
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