甲磺酸赖氨酸安非他命
甲磺酸赖氨酸安非他命(英語:),名字来源为“離胺酸-右旋安非他命”,是 中樞神經系統(CNS)右旋安非他命刺激剂的前体药物,一种安非他命类的苯乙胺衍生物,用于治疗注意力不足過動症(ADHD)和過胖暴食症。[4][5]
系统(IUPAC)命名名称 | |
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(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide | |
临床数据 | |
Drugs.com | Monograph |
MedlinePlus | a607047 |
医疗法规 |
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妊娠分级 | |
依赖性 | 身体依赖: 无 精神依赖: 中等 |
成瘾性 | 中等 |
给药途径 | 口服(胶囊) |
合法狀態 | |
合法状态 |
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药代动力学数据 | |
生物利用度 | 96.4%[1] |
代谢 | 起初由红血球水解。 余下的代谢过程同安非他命#药物代谢动力学。 |
開始出現藥效 | 2小时[2][3] |
生物半衰期 | ≤1小时(前体药物分子) 9至11小时(右旋安非他命) |
作用时间 | 12 hours[2][3] |
排泄 | 肾脏:约2% |
识别 | |
CAS注册号 | 608137-32-2 [IUPHAR] |
ATC代码 | N06BA12 |
PubChem | CID 11597698 |
IUPHAR/BPS | 7213 |
DrugBank | DB01255 |
ChemSpider | 9772458 [Chemspider] |
UNII | H645GUL8KJ |
ChEMBL | CHEMBL1201222 |
其他名称 | Vyvanse |
化学 | |
化学式 | C15H25N3O |
摩尔质量 | 263.378 g/mol |
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参考资料
- (PDF). Shire Pharmaceuticals Contracts Limited: 14. [2014-08-23]. (原始内容存档 (PDF)于2014-08-26).
- Millichap JG. . Millichap JG (编). 2nd. New York, USA: Springer. 2010: 112. ISBN 9781441913968.
Table 9.2 Dextroamphetamine formulations of stimulant medication
Dexedrine [Peak:2–3 h] [Duration:5–6 h] ...
Adderall [Peak:2–3 h] [Duration:5–7 h]
Dexedrine spansules [Peak:7–8 h] [Duration:12 h] ...
Adderall XR [Peak:7–8 h] [Duration:12 h]
Vyvanse [Peak:3–4 h] [Duration:12 h] - Brams M, Mao AR, Doyle RL. . Postgrad. Med. September 2008, 120 (3): 69–88. PMID 18824827. doi:10.3810/pgm.2008.09.1909.
Onset of efficacy was earliest for d-MPH-ER at 0.5 hours, followed by d, l-MPH-LA at 1 to 2 hours, MCD at 1.5 hours, d, l-MPH-OR at 1 to 2 hours, MAS-XR at 1.5 to 2 hours, MTS at 2 hours, and LDX at approximately 2 hours. ... MAS-XR, and LDX have a long duration of action at 12 hours postdose
- (PDF). United States Food and Drug Administration. Shire US Inc. January 2015 [2015-02-24]. (原始内容存档 (PDF)于2015-02-25).
- Heal DJ, Smith SL, Gosden J, Nutt DJ. . J. Psychopharmacol. June 2013, 27 (6): 479–496. PMC 3666194. PMID 23539642. doi:10.1177/0269881113482532.
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