甲磺酸赖氨酸安非他命

**甲磺酸赖氨酸安非他命**
系统（IUPAC）命名名称
	(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
临床数据
Drugs.com	Monograph
MedlinePlus	a607047
医疗法规	US FDA: Lisdexamfetamine;
妊娠分级	AU: B3 ; US: C (不排除有风险的可能) ;
依赖性	身体依赖: 无; 精神依赖: 中等
成瘾性	中等
给药途径	口服（胶囊）
合法狀態
合法状态	AU: 受管控 (S8) ; CA: Schedule I ; DE: Anlage III ; UK: Class B ; US: Schedule II ; 处方药（℞-only）;
药代动力学数据
生物利用度	96.4%[1]
代谢	起初由红血球水解。; 余下的代谢过程同安非他命#药物代谢动力学。
開始出現藥效	2小时[2][3]
生物半衰期	≤1小时（前体药物分子）; 9至11小时（右旋安非他命）
作用时间	12 hours[2][3]
排泄	肾脏：约2%
识别
CAS注册号	608137-32-2 [IUPHAR]
ATC代码	N06BA12
PubChem	CID 11597698
IUPHAR/BPS	7213
DrugBank	DB01255
ChemSpider	9772458 [Chemspider]
UNII	H645GUL8KJ
ChEMBL	CHEMBL1201222
其他名称	Vyvanse
化学
化学式	C15H25N3O
摩尔质量	263.378 g/mol
	SMILES O=C(N[C@H](Cc1ccccc1)C)[C@@H](N)CCCCN;
	InChI InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1 ; Key:VOBHXZCDAVEXEY-JSGCOSHPSA-N ;

甲磺酸赖氨酸安非他命（英語：），名字来源为“離胺酸-右旋安非他命”，是中樞神經系統（CNS）右旋安非他命刺激剂的前体药物，一种安非他命类的苯乙胺衍生物，用于治疗注意力不足過動症（ADHD）和過胖暴食症。[4][5]

30毫克Vyvanse胶囊

参考资料

(PDF). Shire Pharmaceuticals Contracts Limited: 14. [2014-08-23]. （原始内容存档 (PDF)于2014-08-26）.
Millichap JG. . Millichap JG (编). 2nd. New York, USA: Springer. 2010: 112. ISBN 9781441913968.
Table 9.2 Dextroamphetamine formulations of stimulant medication
Dexedrine [Peak:2–3 h] [Duration:5–6 h] ...
Adderall [Peak:2–3 h] [Duration:5–7 h]
Dexedrine spansules [Peak:7–8 h] [Duration:12 h] ...
Adderall XR [Peak:7–8 h] [Duration:12 h]
Vyvanse [Peak:3–4 h] [Duration:12 h]
Brams M, Mao AR, Doyle RL. . Postgrad. Med. September 2008, 120 (3): 69–88. PMID 18824827. doi:10.3810/pgm.2008.09.1909. Onset of efficacy was earliest for d-MPH-ER at 0.5 hours, followed by d, l-MPH-LA at 1 to 2 hours, MCD at 1.5 hours, d, l-MPH-OR at 1 to 2 hours, MAS-XR at 1.5 to 2 hours, MTS at 2 hours, and LDX at approximately 2 hours. ... MAS-XR, and LDX have a long duration of action at 12 hours postdose
(PDF). United States Food and Drug Administration. Shire US Inc. January 2015 [2015-02-24]. （原始内容存档 (PDF)于2015-02-25）.
Heal DJ, Smith SL, Gosden J, Nutt DJ. . J. Psychopharmacol. June 2013, 27 (6): 479–496. PMC 3666194. PMID 23539642. doi:10.1177/0269881113482532.

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