癸酸诺龙

癸酸诺龙英語:商品名为Deca-Durabolin)是一种雄激素同化類固醇(AAS)药物,主要用于治疗贫血惡病體質,以及患骨質疏鬆症更年期女性[7][8][9][10][4]。通过每1-4周一次的肌肉注射进行给药[4]

19-去甲睾酮(Nandrolone,诺龙),癸酸诺龙的最终活性形式
癸酸诺龙
系统(IUPAC)命名名称
[(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] decanoate
临床数据
商品名Deca-Durabolin, others
妊娠分级
  • AU: D
  • US: X (禁忌)
给药途径Intramuscular injection
合法狀態
合法状态
药代动力学数据
生物利用度Intramuscular: 53–73%[1]
代谢Blood (hydrolysis), liver (reduction)[2][3]
代謝產物Nandrolone[2][4]
5α-Dihydronandrolone[2][4]
19-Norandrosterone[2]
19-Noretiocholanolone[2]
Conjugates[3]
生物半衰期• Intramuscular: 6–12 days[2][5]
• Nandrolone: <4.3 hours[2]
作用时间• Intramuscular: 2–3 weeks[4][6]
排泄Urine[2]
识别
CAS注册号360-70-3
PubChemCID 9677
ChemSpider9296
UNIIH45187T098
其他名称• Nandrolone decylate
• 19-Nortestosterone 17β-decanoate
化学
化学式C28H44O3
摩尔质量428.66 g·mol−1

参考文献

  1. Bagchus WM, Smeets JM, Verheul HA, De Jager-Van Der Veen SM, Port A, Geurts TB. . J. Clin. Endocrinol. Metab. 2005, 90 (5): 2624–30. PMID 15713722. doi:10.1210/jc.2004-1526.
  2. http://www.medsafe.govt.nz/profs/Datasheet/d/Decadurabolininj.pdf
  3. William Llewellyn. . Molecular Nutrition Llc. 2011: 402–412,193–194. ISBN 978-0-9828280-1-4.
  4. Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ. . J. Pharmacol. Exp. Ther. 1997, 281 (1): 93–102. PMID 9103484.
  5. J. Elks. . Springer. 14 November 2014: 660–. ISBN 978-1-4757-2085-3.
  6. . Taylor & Francis. January 2000: 716–717. ISBN 978-3-88763-075-1.
  7. I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 6 December 2012. ISBN 978-94-011-4439-1.
  8. . [2019-03-04]. (原始内容存档于2019-08-28).
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