多巴胺受體D₂

D2R屬於一種多巴胺受體，並會與G_i結合。G_i為G蛋白偶联受体的一種亞型，會抑制腺苷酸环化酶的活性[7]。

在小鼠模式中，齒狀回的neuronal calcium sensor-1（NCS-1）會影響D2R在細胞膜的表現量。這項機制會影響突触可塑性及記憶形成[8]。

在蒼蠅模式中，多巴胺性神經元上的D2R自體受器能避免神經元死亡，進而引發類帕金森氏症的症狀[9]。

Alternative splicing of this gene results in three transcript variants encoding different isoforms.[10]

The long form (D2Lh) has the "canonical" sequence and functions as a classic post-synaptic receptor.[11]The short form (D2Sh) is pre-synaptic and functions as an autoreceptor that regulates the levels of dopamine in the synaptic cleft.[11]Agonism of D2sh receptors inhibits dopamine release; antagonism increases dopaminergic release.[11]A third D2(Longer) form differs from the canonical sequence where 270V is replaced by VVQ.[12]

等位基因變異：

• A-241G
• C132T、G423A、T765C、C939T、C957T，以及G1101A[13]
• Cys311Ser
• -141C insertion/deletion[14]The polymorphisms have been investigated with respect to association with schizophrenia.[15]

Some researchers have previously associated the polymorphism Taq 1A (rs1800497) to the DRD2 gene. However, the polymorphism resides in exon 8 of the ANKK1 gene.[16]DRD2 TaqIA polymorphism has been reported to be associated with an increased risk for developing motor fluctuations but not hallucinations in Parkinson's disease.[17][18]

Most of the older antipsychotic drugs such as chlorpromazine and haloperidol are antagonists for the dopamine D₂ receptor, but are, in general, very unselective, at best selective only for the "D₂-like family" receptors and so binding to D₂, D₃ and D₄, and often also to many other receptors such as those for serotonin and histamine, resulting in a range of side-effects and making them poor agents for scientific research. In similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D₂ agonists, they affect other subtypes as well. Several selective D₂ ligands are, however, now available, and this number is likely to increase as further research progresses.

The dopamine receptor D₂ has been shown to interact with EPB41L1,[30]PPP1R9B[31]and NCS-1.[32]

• MeSH（醫學主題詞）上面的Receptors,+Dopamine+D2（美式英语）
• Pappas, Stephanie. . Imaginova Corp. LiveScience. [20 January 2011].

多巴胺受體D2引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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