甘珀酸

甘珀酸英語:,缩写CBX)是一种甾体激素类似物,为甘草次酸丁二酸在3β羟基位置形成的酯,和光果甘草根部中提取的甘草酸结构上类似[1]

甘珀酸
系统(IUPAC)命名名称
(3β)-3-[(3-carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid
OR
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
临床数据
Drugs.com国际药品名称
识别
CAS注册号5697-56-3  N
ATC代码A02BX01
PubChemCID 636403
IUPHAR/BPS4151
DrugBankDB02329 
ChemSpider552190 
UNIIMM6384NG73 
ChEMBLCHEMBL499915 
化学
化学式C34H50O7
摩尔质量570.765 g/mol

甘珀酸可抑制11β-羟基类固醇脱氢酶(11β-HSD)将可的松转化为皮質醇[2][3]

另见

参考文献

  1. Connors BW. . Epilepsy Curr. 2012, 12 (2): 66–8. PMC 3316363. PMID 22473546. doi:10.5698/1535-7511-12.2.66.
  2. .
  3. (PDF).


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