甘珀酸
甘珀酸(英語:,缩写CBX)是一种甾体激素类似物,为甘草次酸与丁二酸在3β羟基位置形成的酯,和光果甘草根部中提取的甘草酸结构上类似[1]。
系统(IUPAC)命名名称 | |
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(3β)-3-[(3-carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid OR (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid | |
临床数据 | |
Drugs.com | 国际药品名称 |
识别 | |
CAS注册号 | 5697-56-3 |
ATC代码 | A02BX01 |
PubChem | CID 636403 |
IUPHAR/BPS | 4151 |
DrugBank | DB02329 |
ChemSpider | 552190 |
UNII | MM6384NG73 |
ChEMBL | CHEMBL499915 |
化学 | |
化学式 | C34H50O7 |
摩尔质量 | 570.765 g/mol |
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甘珀酸可抑制11β-羟基类固醇脱氢酶(11β-HSD)将可的松转化为皮質醇[2][3]。
参考文献
- Connors BW. . Epilepsy Curr. 2012, 12 (2): 66–8. PMC 3316363. PMID 22473546. doi:10.5698/1535-7511-12.2.66.
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- (PDF).
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