去甲腎上腺素轉運體

去甲腎上腺素轉運體
識別號
别名	SLC6A2；, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
外部ID	OMIM：163970 MGI：1270850 HomoloGene：816 GeneCards：SLC6A2
為以下藥物的標靶
	阿米替林、阿莫沙平、阿托莫西汀、丁氨苯丙酮、西酞普兰、氯米帕明、地昔帕明、去甲文拉法辛、右旋安非他命、度洛西汀、丙咪嗪、levomilnacipran、洛非帕明、马普替林、馬吲哚、哌甲酯、奈法唑酮、nisoxetine、nomifensine、去甲替林、苯乙肼、普罗替林、喹硫平、esreboxetine、西布曲明、tapentadol、曲米帕明、文拉法辛、zotepine[1]
基因位置（人类）
染色体	染色体16（人类）[2]
终止	55,706,192 bp[2]
基因位置（小鼠）
染色体	染色体8（小鼠）[3]
终止	93,001,667 bp[3]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• dopamine:sodium symporter activity; • neurotransmitter:sodium symporter activity; • norepinephrine:sodium symporter activity; • monoamine transmembrane transporter activity; • 血浆蛋白结合; • symporter activity; • 金屬離子結合; • beta-tubulin binding; • alpha-tubulin binding; • actin binding;
細胞組分	• integral component of membrane; • 细胞膜; • 膜; • 脂筏模型; • neuron projection; • cell surface; • integral component of plasma membrane; • neuronal cell body membrane; • presynaptic membrane;
生物學過程	• dopamine uptake involved in synaptic transmission; • neurotransmitter transport; • response to pain; • monoamine transport; • chemical synaptic transmission; • norepinephrine transport; • transmembrane transport; • response to drug; • sodium ion transmembrane transport; • norepinephrine uptake; • neuron cellular homeostasis; • 再攝取;
	Sources:Amigo / QuickGO
直系同源
	6530
	20538
	ENSG00000103546
	ENSMUSG00000055368
	P23975
	O55192
	XR_933403、NM_001043、NM_001172501、NM_001172502、NM_001172504、XM_006721263、XM_011523295、XM_011523296、XM_011523297、XM_011523298、XM_011523299、XM_011523300
	NM_009209、XM_006530793、XM_006530794
	NP_001034、NP_001165972、NP_001165973、NP_001165975、XP_006721326、XP_011521597、XP_011521598、XP_011521599、XP_011521600、XP_011521601、XP_011521602
	NP_033235、XP_006530856、XP_006530857
	維基數據

去甲腎上腺素轉運體（英語：，NET），也被稱為溶質載體家族6成員2(英語：，SLC6A2)，是由SLC6A2基因編碼的蛋白質。[6]。NET是一种單胺轉運體，負責依賴Na⁺/Cl⁻的胞外去甲腎上腺素再攝取。NET也可轉運多巴胺。對這兩種神经递质的再吸收是調控突觸間隙傳導物濃度的重要機制。

NET以及其他單胺轉運體是不少抗抑鬱劑以及娛樂性藥物的作用對象。過少的NET跟直立不耐症相關，過多NET則和ADHD相關。[7][8]

參見

神經遞質轉運體
Sodium:neurotransmitter symporter
溶質載體家族
去甲肾上腺素
單胺轉運體
直立不耐症
單核苷酸多態性

参考资料

.
GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Pacholczyk T, Blakely RD, Amara SG. . Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. . The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
Tellioglu T, Robertson D. . Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.

外部链接

MeSH（醫學主題詞）上面的Norepinephrine+transporter（美式英语）

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2008212-6] Pacholczyk T, Blakely RD, Amara SG. . Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.

[7] Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. . The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.

[pmid14987367-8] Tellioglu T, Robertson D. . Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.